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Alcohol causes irreparable damage in DNA of stem cells: Research

Monday March 5, 2018 1:50 PM, Agencies


London: Alcohol causes irreparable damage in the DNA of stem cells, enhancing the risk of developing cancer, and costing some hard drinkers “more than just a hangover,” British scientists say.

Researchers at the MRC Laboratory of Molecular Biology, Cambridge, gave diluted alcohol (ethanol) to mice. Afterwards they used chromosome analysis and DNA sequencing to study the genetic damage caused by a harmful chemical (known as acetaldehyde) produced when the body processes alcohol.

Scientists discovered that acetaldehyde can break and damage DNA within blood stem cells, causing rearranged chromosomes as well as permanently altering the DNA sequences within these cells.

Researchers highlighted the importance of understanding the DNA blueprint within stem cells citing one simple reason: when healthy stem cells are corrupted, they can give rise to cancer. Their findings demonstrate how drinking alcohol boosts the risk of developing 7 types of cancer, including the most common types – breast and bowel.

“Some cancers develop due to DNA damage in stem cells. While some damage occurs by chance, our findings suggest that drinking alcohol can increase the risk of this damage,” Professor Ketan Patel, the lead author of the study and scientist at the MRC Laboratory of Molecular Biology, said in a press-release.

The study also closely inspected the way our body tries to protect itself against damage caused by alcohol. The first line of defense is a family of enzymes called aldehyde dehydrogenases (ALDH), researchers said.

These enzymes break down harmful acetaldehyde into acetate, which our cells can use as a source of energy. The problem is, millions of people, especially those from South East Asia, either lack these enzymes or carry faulty versions of them. As a result, while they drink, acetaldehyde builds up, causing a flushed complexion along with as a feeling of discomfort.

In the British scientists’ study, when mice lacking the critical ALDH enzyme (ALDH2) were given alcohol, it resulted in four times as much DNA damage in their cells compared with mice with the fully-functioning enzyme.

Cells also have a second line of defense in a variety of DNA repair systems. Although most of the time they reverse different types of DNA damage, some people carry mutations so their cells aren’t capable of carrying out any such ‘repair work.’

“Our study highlights that not being able to process alcohol effectively can lead to an even higher risk of alcohol-related DNA damage and therefore certain cancers,” Professor Patel noted. “But it’s important to remember that alcohol clearance and DNA repair systems are not perfect and alcohol can still cause cancer in different ways, even in people whose defense mechanisms are intact,” he concluded.

Professor Linda Bauld, Cancer Research UK’s expert on cancer prevention, added that this “thought-provoking research,”published in the journal Nature on Wednesday, highlights the “damage alcohol can do to our cells, costing some people more than just a hangover.”

“We know that alcohol contributes to over 12,000 cancer cases in the UK each year, so it’s a good idea to think about cutting down on the amount you drink,” she said.

The International Agency for Research on Cancer (IARC), a World Health Organization body, has classified alcohol as a Group 1 carcinogen, along with tobacco, asbestos and formaldehyde.

Scientists from Cancer Research UK warned in 2016 that alcohol would cause around 135,000 cancer deaths over the next two decades, and that by 2035, the UK could see 7,097 cancer deaths linked to drinking every year.

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