Washington: Stents, normally
used to halt tissue growth in arteries, are known to have life
threatening side effects such as increasing the likelihood of blood
clots and heart attacks. Now, researchers have developed a computer
model that explains why those drugs released from stents accumulate
in the arteries and cause blood clots.
The model will
allow the scientists to predict drug distribution in branched
explain why drugs can pile up in certain areas, depending on where
the stent is placed relative to forks in the artery.
"By observing the
arterial drug distribution patterns for various settings, we
understood that drug released from the stent does not reach
uniformly to all regions of the vessel and this non-uniformity
depends on where the stent is placed in the artery as well as the
blood flow that is entering the vessel," said Edelman.
The new study
would help stent developers design safer and more effective stents.
It also raises the
possibility of designing individualized stents for patients. It
could aid the FDA in its approval process for stents.
The results of the
study appear in PLoS One. (ANI)