Follow us on
Welcome Guest! You are here: Home » Health
Trial drug slows brain's shrinking: Research

Sunday September 2, 2018 5:51 PM, News Network

Chicago: A phase two clinical trial of the investigational drug ibudilast shows that the drug slows brain shrinkage.

The study involves 28 clinical sites including Washington University School of Medicine, where 255 patients were randomly assigned to take up to 10 capsules of ibudilast or a placebo daily for nearly two years. Every six months, the participants underwent MRI brain scans. The researchers applied a variety of analysis techniques to the MRI images to assess differences in brain changes between the two groups, according to Xinhua.

The researchers found the brains of patients in both groups continued to atrophy over the course of the study, but the decline was slower in the ibudilast group. Reducing the rate of atrophy may delay the worsening of symptoms.

"The study was not large enough to prove a clinical effect, but the data suggest that people's disabilities may not have worsened as rapidly in the treatment group," said co-author Robert T. Naismith, an associate professor of neurology at Washington University School of Medicine.

The most common side effects reported by participants included nausea and diarrhea, as well as headaches and depression. There was no significant difference between the groups in the number of patients who reported adverse effects.

People with a progressive form of multiple sclerosis (MS) face a gradual decline of brain function that slowly strips away the ability to walk and may cause problems with speech and vision. The finding provides a glimmer of hope for people with a form of MS.

Future research will test whether reducing brain shrinkage affects thinking, walking and other problems in people with MS, and will examine whether ibudilast slows the progression of disability in MS patients.

The study was published on August 29 in the New England Journal of Medicine.

For all the latest News, Opinions and Views, download App

Select Langauge To Read in Urdu, Hindi, Marathi or Arabic

Share this page
More Headlines
Arafat Valley reverberates with Talbiyah as over 02 million pilgrims perform Hajj
Heavy rains, dust storm greet pilgrims as they prepare to move to Plains of Mount Arafat
Video: Kaaba’s Kiswa buffeted by high winds in Makkah a day before Youme Arafah
Micro, Small and Medium Enterprises worst hit by GST, demonetisation: RBI
In hours, Indian businesses in UAE donate $2.7 million for Kerala flood victims
Researchers create new AI-powered camera for faster image processing
Situation in Kerala extremely grim, panic all across the state; Death toll 320
Finest orator and parliamentarian, but Vajpayee was never a Great Prime Minister
Kids do not overeat, but substitute when given extra time: Study
MIM corporator beaten, Professor thrown out of home for criticising Atal Bihari Vajpayee
Saudi Arabia denies collapse of any building in Makkah ahead of Hajj
Imran Khan formally elected as Prime Minister of Pakistan
This 14-year-old schoolboy is running for governor in America's northeastern state
Muslims After Four Years Of Narendra Modi Rule In India
Tired of corrupt governance system, Doctor turned IAS Officer resigns, to join NGO
All indications suggest that PM Modi will opt for Lok Sabha Elections in December
Don't damage Muslim-Hindu relations, India is large enough for both of us
Beware - Mixing energy drinks and alcohol has ill effects
Why Independence Day is Important: Dr Nowhera Shaikh explains in touching message
Muzaffarnagar riot cases can't be withdrawn: Top Official to UP Govt
 Post Comments
Note: By posting your comments here you agree to the terms and conditions of