Vaccines for heart attacks to be ready
within 5 years
Sunday April 01, 2012 08:34:18 PM,
IANS
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London: Vaccines
targeting the build-up of fatty deposits in arteries (plaques)
could be available within five years to prevent heart attacks.
It would be addressing the actual causes of heart disease rather
than targeting factors such as high levels of bad cholesterol and
blood pressure.
Lack of exercise, poor diet, smoking and drinking too much alcohol
are the main causes of heart disease but there are strong
hereditary factors too, the Telegraph reports.
Dan Nilsson, professor of experimental cardiovascular research at
Lund University, Sweden said: "People at high risk of heart
attacks are likely to be the first candidates for immune
approaches. Such treatments, since they have totally different
modes of action, could be used in addition to the current
therapies."
Working with Prediman Shah, professor at Cedars-Sinai Heart
Institute in Los Angeles, US, the team were able to formulate a
vaccine that reduced plaque build up by 60 to 70 percent in mice.
The resulting CVX-210 vaccine, being developed as an injection by
CardioVax, is awaiting regulatory clearance to start clinical
trials.
Coronary heart disease occurs when fatty plaques build up in the
blood vessels feeding the heart and over time become narrowed.
Parts of the plaque may break off causing a clot which can block
teh artery, causing a heart attack.
These findings were presented at the CardioVascular Biology
meeting at Imperial College London.
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