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Faulty genes precipitate bowel cancer risk
Tuesday December 25, 2012 11:52:36 AM,
IANS
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London: Faulty genes precipitate bowel cancer risk
in families which have a history of this condition, according to a
British study.
Researchers from Oxford University and The Institute of Cancer
Research, London, found everyone who had a faulty gene 'POLE' or
'POLD1' developed bowel cancer or had a precancerous growth in the
bowel.
The researchers then further looked at 4,000 people with bowel
cancer and 6,700 healthy people, the journal Nature Genetics
reports.
Neither of the faults were found in people without bowel cancer,
while 12 people with the POLE gene were found in the bowel cancer
group and a person had a POLD1 gene fault, according to the
Telegraph.
POLE and POLD1 are involved in scanning and repairing damage to
DNA, removing incorrect sequences from the DNA chain. Without
them, affected individuals build up damage in their DNA which can
cause bowel cancer.
The POLD1 fault was also found to increase the risk of getting
womb cancer and possibly brain tumours with seven people in the
study being diagnosed with womb cancer and one developing two
brain tumours.
Richard Houlston, professor from The Institute of Cancer Research
said: "Uncovering gene faults like these two is extremely
important, as inherited susceptibility plays a role in the
development of about a third of all the cases of Colorectal
Cancer."
"This is one of the most important discoveries in bowel cancer
genetics in years. It should allow us to manage families affected
by inherited bowel cancer much more effectively, and it offers new
clues for the prevention or treatment of all forms of the
disease," Houlston concluded.
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