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Hybrid device can print implantable cartilage
Saturday November 24, 2012 11:10:36 AM,
IANS
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London: A hybrid
printer developed by scientists will help print 3D tissue that
simplifies the process of creating implantable cartilage that
could eventually be implanted into injured patients to help
re-grow cartilage in specific areas, such as the joints.
The printer is a combination of two low-cost fabrication
techniques: a traditional ink jet printer and an electrospinning
machine, the journal Biofabrication reports.
Combining these systems allowed scientists to build a structure
made from natural and synthetic materials. Synthetic materials
ensure the strength of the construct and the natural gel materials
provide an environment that promotes cell growth.
"This is a proof of concept study and illustrates that a
combination of materials and fabrication methods generates durable
implantable constructs," said James Yoo, professor at the Wake
Forest Institute for Regenerative Medicine, and study author.
"Other methods of fabrication, such as robotic systems are
currently being developed to further improve the production of
implantable tissue constructs," added Yoo, according to a Wake
Forest statement.
In this study, the hybrid system produced cartilage constructs
with increased mechanical stability compared to those created by
an ink jet printer using gel material alone. The constructs were
also shown to maintain their functional characteristics in the lab
and a real-life system.
The key to this was the use of the electrospinning machine, which
uses electrical current to generate very fine fibres from a
polymer solution.
Electrospinning allows the composition of polymers to be easily
controlled and therefore produces porous structures that encourage
cells to integrate into surrounding tissue.
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