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‘Retinoblastoma’ can be cured if identified and treated early

Wednesday May 30, 2018 11:12 AM, Dr Rajesh Ramanjulu,

Eye Cancer

Retinoblastoma is the most common intraocular malignancy of childhood which represents 3% of all childhood cancers; it can be fatalistic if not treated. Doctors across the world have been trying to evolve retinoblastoma treatment protocols with an aim not only to preserve life and eye, but also optimize residual vision.

Retinoblastoma is the most common childhood eye cancer affecting children less than 5 years of age. It can affect any socioeconomic group without any racial or gender preference. It can affect either one or both eyes. It is a type of eye cancer that begins in the retina — the sensitive lining on the inside of the eye. It may occur in one or both eyes. Retinoblastoma commonly affects young children.


  1. Symptoms can be varied in retinoblastoma. One can often recognize retinoblastoma when a parent or doctor notices a child’s eye looks unusual.
  2. The most common presentation of this disease is with abnormal light reflex “white eye”, or “cat’s eye reflex” noted by parents during flash light photography as a white reflex.
  3. It can be present as squinting of eyes (cross/ lazy eyes) or unexplained redness of eyes with lid tenderness or abnormal enlargement of the eye ball.
  4. The symptoms for retinoblastoma of benign conditions of the eye can premiere retinoblastoma and so it is advisable to seek medical care at earliest.

If your child has any of these symptoms, contact an ophthalmologist right away.


When diagnosed early there is a good chance of both vision and eye ball preservation. In some cases, when diagnosed late, the eye ball might have to be removed to prevent spread of the cancer in the whole body.

Management strategies include medical (chemotherapy, radiotherapy), surgical – removal of eye ball or local radiation therapy (brachytherapy), local therapy (laser, cryo etc). The newest modality of treatment SSIAC (Supra Selective Intra Arteriole Chemo Therapy) can be utilized with minimal side effects of the chemotherapy drugs to the body.

Management of retinoblastoma requires co-ordination between ophthalmologist, neurosurgeon, oncologist, ocularist (artificial eye implants) and anesthetist as the child requires frequent eye examinations under general anesthesia to look for progression of disease, sometimes even after eye removal to look for any new cancer development in the other eye or in the orbit.

Retinoblastoma is a rare cancer, so your child's doctor may explore other more common eye conditions first. Siblings should also be screened to look for any unnoticed eye lesion as the disease is known to have some familial predisposition in certain cases.

Retinoblastoma is a deadly eye cancer which can be treated and cured if identified and treated early, and the children with Retinoblastoma will live to see the world.

[The writer, Dr Rajesh Ramanjulu, is Consultant Vitreo Retina& Ocular Oncology, Sankara Eye Hospital in Bengaluru]

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