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Gut bugs
could prevent efficacy of cholesterol drugs
Friday October 14, 2011 12:22:26 PM,
IANS
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Washington: Statin
drugs are quite good at busting cholesterol but they may work for
some and not others because of gut bacteria, new research says.
A team led by a Duke University Medical Centre scientist has
identified three bile acids produced by gut bacteria in people who
responded well to a common cholesterol-busting drug called
simvastatin.
The finding demonstrates how gut bacteria can cause inherent
differences in the way people digest, metabolise and benefit from
substances such as drugs, reports the journal Public Library of
Science One.
The study represents an analysis of the intestinal microflora and
metabolomics, a discipline that examines thousands of biochemical
components involved in cellular metabolism, according to a Duke
statement.
"This is personalised medicine - the effects of drugs and how we
respond," said Rima Kaddurah-Daouk, associate professor in
psychiatry at Duke's.
"We found that the benefit of statins could be partly related to
the type of bacteria that lives in our guts. The reason we respond
differently is not only our genetic makeup, but also our gut
microbiome," Kaddurah-Daouk added.
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